A G protein-biased peptide agonist of GLP-1R
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Utreglutide

Item No. 41275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-methylalanyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycyl-L-leucine
CAS Number
2460862-12-6
Synonyms
  • GL0034
Molecular Formula
C191H298N46O58
Formula Weight
4166.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)C[C@@H](C(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(COCCOCCNC(C(C)(C)NC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC5=CC=CC=C5)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(O)=O)NC(C(C)(C)NC([C@H](CC6=CNC=N6)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C191H298N46O58/c1-22-106(12)155(181(285)211-109(15)160(264)220-134(87-115-90-203-120-54-44-43-53-118(115)120)171(275)222-130(82-102(4)5)172(276)232-153(104(8)9)179(283)219-122(57-48-76-202-189(196)197)163(267)205-92-143(247)212-121(56-47-75-201-188(194)195)162(266)204-94-145(249)215-136(185(290)291)83-103(6)7)234-173(277)132(84-112-49-37-35-38-50-112)223-168(272)127(68-73-151(258)259)218-167(271)123(55-45-46-74-199-147(251)99-295-80-79-294-78-77-200-186(292)190(18,19)236-142(246)70-65-128(184(288)289)214-141(245)58-41-33-31-29-27-25-23-24-26-28-30-32-34-42-59-148(252)253)216-159(263)108(14)209-158(262)107(13)210-166(270)126(64-69-140(193)244)213-144(248)93-206-164(268)124(66-71-149(254)255)217-169(273)129(81-101(2)3)221-170(274)131(86-114-60-62-117(243)63-61-114)224-176(280)137(96-238)227-178(282)139(98-240)228-180(284)154(105(10)11)233-175(279)135(89-152(260)261)225-177(281)138(97-239)229-183(287)157(111(17)242)235-174(278)133(85-113-51-39-36-40-52-113)226-182(286)156(110(16)241)231-146(250)95-207-165(269)125(67-72-150(256)257)230-187(293)191(20,21)237-161(265)119(192)88-116-91-198-100-208-116/h35-40,43-44,49-54,60-63,90-91,100-111,119,121-139,153-157,203,238-243H,22-34,41-42,45-48,55-59,64-89,92-99,192H2,1-21H3,(H2,193,244)(H,198,208)(H,199,251)(H,200,292)(H,204,266)(H,205,267)(H,206,268)(H,207,269)(H,209,262)(H,210,270)(H,211,285)(H,212,247)(H,213,248)(H,214,245)(H,215,249)(H,216,263)(H,217,273)(H,218,271)(H,219,283)(H,220,264)(H,221,274)(H,222,275)(H,223,272)(H,224,280)(H,225,281)(H,226,286)(H,227,282)(H,228,284)(H,229,287)(H,230,293)(H,231,250)(H,232,276)(H,233,279)(H,234,277)(H,235,278)(H,236,246)(H,237,265)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,288,289)(H,290,291)(H4,194,195,201)(H4,196,197,202)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,153-,154-,155-,156-,157-/m0/s1
InChi Key
ZEIOLHQKVVWWKF-QJDBRWKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Utreglutide is a G protein-biased peptide agonist of glucagon-like peptide 1 receptor (GLP-1R).1 It selectively induces cAMP accumulation in HEK293 cells expressing human GLP-1R over β-arrestin recruitment in CHO-K1 cells expressing human GLP-1R (EC50s = 0.63 and 79 nM, respectively). Utreglutide induces insulin secretion in INS-1 832/3 rat insulinoma cells (EC50 = 6.3 nM). In vivo, utreglutide (1.5-6 nmol/kg) reduces food intake and body weight, increases plasma insulin levels, and decreases plasma glucose, hemoglobin A1c (HbA1c), glucagon, and triglyceride levels in diabetic db/db mice.

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    References & Product Citations
    Product Description References

    1. Jones, B., Burade, V., Akalestou, E., et al. In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist. Diabetes Obes. Metab. 24(11), 2090-2101 (2022).