BI-99179

BI-99179 is an inhibitor of fatty acid synthase type I (FAS-I; IC₅₀ = 79 nM), a multifunctional enzyme that catalyzes the conversion of acetyl-coenzyme A (acetyl-CoA; Item No. 16160) and malonyl-CoA (Item No. 16455) to long-chain fatty acids.¹ It is selective for FAS-I over 30 other enzymes, receptors, and ion channels at 10 µM. BI-99179 inhibits the incorporation of ¹⁴C-acetate in mouse N-42 hypothalamus cells (IC₅₀ = 570 nM). It reduces the proliferation of GaMG human glioma cells when used at a concentration of 10 µM.²

WARNING This product is not for human or veterinary use.

1. Kley, J.T., Mack, J.B.C., Hamilton, B., et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure. Bioorg. Med. Chem. Lett. 21(19), 5924-5927 (2011).

2. Singha, P.K., Mäklin, K., Vihavainen, T., et al. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells. Eur. J. Pharm. Sci. 149, 105321 (2020).