An amylin and calcitonin receptor agonist
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Cagrilintide (acetate)

Item No. 41329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-arginyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-prolyl-L-isoleucyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-prolinamide, cyclic (3→8)-disulfide, acetate salt
Synonyms
  • AM833
  • NN0174-0833
Molecular Formula
C194H312N54O59S2 • XC2H4O2
Formula Weight
4409.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
(Eicosanedioic acid-γ-Glu)-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]2N(CCC2)C([C@H]3N(CCC3)C([C@@H](NC([C@@H](NC([C@H]4N(CCC4)C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC5=O)CC(N)=O)=O)[C@@H](C)O)=O)C)=O)[C@@H](C)O)=O)CSSC[C@@H]5NC([C@@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)CCCCN)=O)=O)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)C)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC7=CNC=N7)=O)CO)=O)CO)=O)CC(N)=O)=O)CC(N)=O)=O)CC8=CC=CC=C8)=O)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)C(C)C)=O)=O)CO)=O)CC(N)=O)=O)[C@@H](C)O)=O)N.CC(O)=O
InChi Code
InChI=1S/C194H312N54O59S2.C2H4O2/c1-19-100(10)151(184(298)233-128(78-98(6)7)189(303)248-75-49-60-137(248)190(304)247-74-48-59-136(247)182(296)243-155(107(17)255)187(301)232-127(86-143(201)262)173(287)238-150(99(8)9)183(297)210-88-146(265)218-129(90-249)176(290)230-126(85-142(200)261)175(289)244-156(108(18)256)191(305)246-73-46-57-134(246)157(202)271)239-181(295)135-58-47-72-245(135)147(266)89-211-161(275)120(79-109-50-36-34-37-51-109)225-171(285)123(82-139(197)258)228-172(286)124(83-140(198)259)229-177(291)130(91-250)235-178(292)131(92-251)234-170(284)122(81-111-87-207-95-212-111)227-164(278)114(56-45-71-209-194(205)206)221-168(282)119(77-97(4)5)224-169(283)121(80-110-52-38-35-39-53-110)226-166(280)116(65-68-149(269)270)219-158(272)101(11)213-167(281)118(76-96(2)3)223-163(277)113(55-44-70-208-193(203)204)220-165(279)115(63-66-138(196)257)222-186(300)153(105(15)253)240-159(273)102(12)214-179(293)132-93-308-309-94-133(180(294)231-125(84-141(199)260)174(288)242-152(104(14)252)185(299)215-103(13)160(274)241-154(106(16)254)188(302)237-132)236-162(276)112(54-42-43-69-195)216-145(264)67-64-117(192(306)307)217-144(263)61-40-32-30-28-26-24-22-20-21-23-25-27-29-31-33-41-62-148(267)268;1-2(3)4/h34-39,50-53,87,95-108,112-137,150-156,249-256H,19-33,40-49,54-86,88-94,195H2,1-18H3,(H2,196,257)(H2,197,258)(H2,198,259)(H2,199,260)(H2,200,261)(H2,201,262)(H2,202,271)(H,207,212)(H,210,297)(H,211,275)(H,213,281)(H,214,293)(H,215,299)(H,216,264)(H,217,263)(H,218,265)(H,219,272)(H,220,279)(H,221,282)(H,222,300)(H,223,277)(H,224,283)(H,225,285)(H,226,280)(H,227,278)(H,228,286)(H,229,291)(H,230,290)(H,231,294)(H,232,301)(H,233,298)(H,234,284)(H,235,292)(H,236,276)(H,237,302)(H,238,287)(H,239,295)(H,240,273)(H,241,274)(H,242,288)(H,243,296)(H,244,289)(H,267,268)(H,269,270)(H,306,307)(H4,203,204,208)(H4,205,206,209);1H3,(H,3,4)/t100-,101-,102-,103-,104+,105+,106+,107+,108+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,
InChi Key
ZVFSCEVVTIADGE-SXJCWIKGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Cagrilintide is an agonist of amylin and calcitonin receptors and an acylated derivative of amylin.1,2 It binds to the amylin 3 receptor (AMY3; IC50 = 170 pM for the human receptor) and calcitonin receptor (IC50 = 223 pM for the human receptor). Cagrilintide activates human AMY3 and calcitonin receptors in reporter assays (EC50s = 49 and 62 pM, respectively). It increases cAMP accumulation in COS-1 cells expressing AMY1, AMY3, or calcitonin receptors (EC50s = 79.43, 114.82, and 43.65 nM, respectively).2 Cagrilintide (250 µM) has a low propensity for inducing amyloid fibril formation with a lag time of 45 hours in a thioflavin T assay.1 Cagrilintide reduces food intake in rats for at least 48 hours after administration of a single dose of 3 or 30 nmol/kg. It reduces body weight, food intake, and fat mass, but does not reduce blood glucose or increase blood insulin levels, in a mouse model of diet-induced obesity when administered at a dose of 100 nmol/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kruse, T., Hansen, J.L., Dahl, K., et al. Development of cagrilintide, a long-acting amylin analogue. J. Med. Chem. 64(15), 11183-11194 (2021).

    2. Fletcher, M.M., Keov, P., Truong, T.T., et al. AM833 is a novel agonist of calcitonin family G protein-coupled receptors: Pharmacological comparison with six selective and nonselective agonists. J. Pharmacol. Exp. Ther. 77(3), 417-440 (2021).

    3. Sun, X., Yang, D., Li, Y., et al. Identification and utility exploration of a highly potent and long-acting bullfrog GLP-1 analogue in GLP-1 and amylin combination therapy. Peptides 177, 171203 (2024).