A dual amylin and calcitonin receptor agonist
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KBP-066 (trifluoroacetate salt)

Item No. 41331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C147H242N46O48S2 • XCF3COOH
Formula Weight
3485.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-CSNLSTCXLGRLSQDLHRLQTYPKTDVGANAP-NH2 (X=Aminoisobutyric Acid)
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
FC(F)(F)C(O)=O.NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC([C@H](C)NC(CNC([C@@H](NC([C@H](CC(O)=O)NC([C@@]([H])(NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC3=CC=C(C=C3)O)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@H](CS)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)NC(C)=O)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)CO)=O)[C@H](O)C)=O)=O)C)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CO)=O)CCC(N)=O)=O)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)=O)CCCCN)=O)[C@H](O)C)=O)=O)C(C)C)=O)=O)=O)CC(N)=O)=O)=O)=O
InChi Code
InChI=1S/C147H242N46O48S2.C2HF3O2/c1-65(2)45-85(186-144(241)147(19,20)191-136(233)100(63-243)185-141(238)114(75(17)199)190-134(231)98(61-196)183-127(224)89(49-69(9)10)175-129(226)92(53-106(152)205)178-133(230)97(60-195)184-135(232)99(62-242)166-76(18)200)117(214)161-58-108(207)167-80(28-23-41-159-145(154)155)118(215)173-88(48-68(7)8)126(223)182-96(59-194)132(229)170-83(36-38-103(149)202)120(217)179-93(54-109(208)209)130(227)176-87(47-67(5)6)125(222)177-90(51-78-56-158-64-163-78)128(225)168-82(29-24-42-160-146(156)157)119(216)174-86(46-66(3)4)124(221)169-84(37-39-104(150)203)122(219)189-113(74(16)198)140(237)181-95(50-77-32-34-79(201)35-33-77)143(240)193-44-26-31-102(193)137(234)171-81(27-21-22-40-148)121(218)188-112(73(15)197)139(236)180-94(55-110(210)211)131(228)187-111(70(11)12)138(235)162-57-107(206)164-71(13)116(213)172-91(52-105(151)204)123(220)165-72(14)142(239)192-43-25-30-101(192)115(153)212;3-2(4,5)1(6)7/h32-35,56,64-75,80-102,111-114,194-199,201,242-243H,21-31,36-55,57-63,148H2,1-20H3,(H2,149,202)(H2,150,203)(H2,151,204)(H2,152,205)(H2,153,212)(H,158,163)(H,161,214)(H,162,235)(H,164,206)(H,165,220)(H,166,200)(H,167,207)(H,168,225)(H,169,221)(H,170,229)(H,171,234)(H,172,213)(H,173,215)(H,174,216)(H,175,226)(H,176,227)(H,177,222)(H,178,230)(H,179,217)(H,180,236)(H,181,237)(H,182,223)(H,183,224)(H,184,232)(H,185,238)(H,186,241)(H,187,228)(H,188,218)(H,189,219)(H,190,231)(H,191,233)(H,208,209)(H,210,211)(H4,154,155,159)(H4,156,157,160);(H,6,7)/t71-,72-,73+,74+,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-,113-,114-;/m0./s1
InChi Key
SWDWXCRJPFYJCF-SHUKXNPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    KBP-066 is a dual amylin and calcitonin (CT) receptor agonist.1 It induces β-arrestin recruitment in cells expressing CT receptor subtype a or the amylin 3 receptor (AMY3) in a concentration-dependent manner. KBP-066 (50 µg/kg) reduces body weight and food intake in rats fed a high-fat diet. It prevents increases in fasting blood glucose levels in fa/fa Zucker diabetic fatty rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sonne, N., Larsen, A.T., Andreassen, K.V., et al. The dual amylin and calcitonin receptor agonist, KBP-066, induces an equally potent weight loss across a broad dose range while higher doses may further improve insulin action. J. Pharmacol. Exp. Ther. 373(1), 92-102 (2020).