A dual amylin and calcitonin receptor agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

KBP-066 (trifluoroacetate salt)

Item No. 41331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C147H242N46O48S2 • XCF3COOH
Formula Weight
3485.9
Purity
≥95%
Formulation
A solid
Peptide Sequence
Ac-CSNLSTCXLGRLSQDLHRLQTYPKTDVGANAP-NH2 (X=Aminoisobutyric Acid)
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
FC(F)(F)C(O)=O.NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC([C@H](C)NC(CNC([C@@H](NC([C@H](CC(O)=O)NC([C@@]([H])(NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC3=CC=C(C=C3)O)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@H](CS)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)NC(C)=O)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)CO)=O)[C@H](O)C)=O)=O)C)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CO)=O)CCC(N)=O)=O)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)=O)CCCCN)=O)[C@H](O)C)=O)=O)C(C)C)=O)=O)=O)CC(N)=O)=O)=O)=O
InChi Code
InChI=1S/C147H242N46O48S2.C2HF3O2/c1-65(2)45-85(186-144(241)147(19,20)191-136(233)100(63-243)185-141(238)114(75(17)199)190-134(231)98(61-196)183-127(224)89(49-69(9)10)175-129(226)92(53-106(152)205)178-133(230)97(60-195)184-135(232)99(62-242)166-76(18)200)117(214)161-58-108(207)167-80(28-23-41-159-145(154)155)118(215)173-88(48-68(7)8)126(223)182-96(59-194)132(229)170-83(36-38-103(149)202)120(217)179-93(54-109(208)209)130(227)176-87(47-67(5)6)125(222)177-90(51-78-56-158-64-163-78)128(225)168-82(29-24-42-160-146(156)157)119(216)174-86(46-66(3)4)124(221)169-84(37-39-104(150)203)122(219)189-113(74(16)198)140(237)181-95(50-77-32-34-79(201)35-33-77)143(240)193-44-26-31-102(193)137(234)171-81(27-21-22-40-148)121(218)188-112(73(15)197)139(236)180-94(55-110(210)211)131(228)187-111(70(11)12)138(235)162-57-107(206)164-71(13)116(213)172-91(52-105(151)204)123(220)165-72(14)142(239)192-43-25-30-101(192)115(153)212;3-2(4,5)1(6)7/h32-35,56,64-75,80-102,111-114,194-199,201,242-243H,21-31,36-55,57-63,148H2,1-20H3,(H2,149,202)(H2,150,203)(H2,151,204)(H2,152,205)(H2,153,212)(H,158,163)(H,161,214)(H,162,235)(H,164,206)(H,165,220)(H,166,200)(H,167,207)(H,168,225)(H,169,221)(H,170,229)(H,171,234)(H,172,213)(H,173,215)(H,174,216)(H,175,226)(H,176,227)(H,177,222)(H,178,230)(H,179,217)(H,180,236)(H,181,237)(H,182,223)(H,183,224)(H,184,232)(H,185,238)(H,186,241)(H,187,228)(H,188,218)(H,189,219)(H,190,231)(H,191,233)(H,208,209)(H,210,211)(H4,154,155,159)(H4,156,157,160);(H,6,7)/t71-,72-,73+,74+,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-,113-,114-;/m0./s1
InChi Key
SWDWXCRJPFYJCF-SHUKXNPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $125

    Add

    10 mg

    $220

    Add

    25 mg

    $482

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    KBP-066 is a dual amylin and calcitonin (CT) receptor agonist.1 It induces β-arrestin recruitment in cells expressing CT receptor subtype a or the amylin 3 receptor (AMY3) in a concentration-dependent manner. KBP-066 (50 µg/kg) reduces body weight and food intake in rats fed a high-fat diet. It prevents increases in fasting blood glucose levels in fa/fa Zucker diabetic fatty rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sonne, N., Larsen, A.T., Andreassen, K.V., et al. The dual amylin and calcitonin receptor agonist, KBP-066, induces an equally potent weight loss across a broad dose range while higher doses may further improve insulin action. J. Pharmacol. Exp. Ther. 373(1), 92-102 (2020).