A dual peptide GCGR and GLP-1R agonist
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NN1177 (trifluoroacetate salt)

Item No. 41333

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C206H323N51O66 • XCF3COOH
Formula Weight
4570.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
NC([C@@]([C@H](O)C)([H])NC([C@H](CCCCNC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CC[C@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)C(O)=O)=O)CO)=O)CCC(O)=O)=O)CO)=O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@@]([C@H](O)C)([H])NC(CNC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@@H](N)CC1=CN=CN1)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)CC(C=C3)=CC=C3O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C206H323N51O66.C2HF3O2/c1-106(2)87-138(182(298)231-126(181(297)255-166(112(12)263)169(212)285)55-41-44-84-218-154(269)75-66-134(199(315)316)226-157(272)78-69-137(202(321)322)238-194(310)150(103-261)249-180(296)133(72-81-163(281)282)236-191(307)147(100-258)228-158(273)77-68-136(201(319)320)227-156(271)76-67-135(200(317)318)225-155(270)58-35-27-25-23-21-19-17-18-20-22-24-26-28-36-59-160(275)276)239-184(300)140(89-108(5)6)241-187(303)145(94-118-97-221-123-52-38-37-51-121(118)123)245-177(293)130(65-74-153(211)268)237-196(312)165(110(9)10)254-189(305)143(91-115-47-31-29-32-48-115)244-178(294)131(70-79-161(277)278)234-175(291)128(57-46-86-220-205(215)216)229-170(286)111(11)224-173(289)127(56-45-85-219-204(213)214)230-174(290)124(53-39-42-82-207)232-192(308)148(101-259)248-179(295)132(71-80-162(279)280)235-183(299)139(88-107(3)4)240-186(302)142(93-117-60-62-120(266)63-61-117)243-176(292)125(54-40-43-83-208)233-193(309)149(102-260)250-185(301)141(90-109(7)8)242-188(304)146(96-164(283)284)246-195(311)151(104-262)251-198(314)168(114(14)265)256-190(306)144(92-116-49-33-30-34-50-116)247-197(313)167(113(13)264)253-159(274)99-222-172(288)129(64-73-152(210)267)252-203(323)206(15,16)257-171(287)122(209)95-119-98-217-105-223-119;3-2(4,5)1(6)7/h29-34,37-38,47-52,60-63,97-98,105-114,122,124-151,165-168,221,258-266H,17-28,35-36,39-46,53-59,64-96,99-104,207-209H2,1-16H3,(H2,210,267)(H2,211,268)(H2,212,285)(H,217,223)(H,218,269)(H,222,288)(H,224,289)(H,225,270)(H,226,272)(H,227,271)(H,228,273)(H,229,286)(H,230,290)(H,231,298)(H,232,308)(H,233,309)(H,234,291)(H,235,299)(H,236,307)(H,237,312)(H,238,310)(H,239,300)(H,240,302)(H,241,303)(H,242,304)(H,243,292)(H,244,294)(H,245,293)(H,246,311)(H,247,313)(H,248,295)(H,249,296)(H,250,301)(H,251,314)(H,252,323)(H,253,274)(H,254,305)(H,255,297)(H,256,306)(H,257,287)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,315,316)(H,317,318)(H,319,320)(H,321,322)(H4,213,214,219)(H4,215,216,220);(H,6,7)/t111-,112+,113+,114+,122-,124-,125-,
InChi Key
RHIKVGDVHRXFIF-UDGBFSPJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    NN1177 is a dual peptide agonist of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R).1 It induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s = 1.83 and 0.92 pM, respectively). In vivo, NN1177 (3-5 nmol/kg) reduces body weight and cumulative food intake in a mouse model of diet-induced obesity. It also reduces body weight, hepatic fat accumulation and fibrosis, and plasma alanine transaminase (ALT) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-fat, high-fructose, and high-cholesterol diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simonsen, L., Lau, J., Kruse, T., et al. Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls. PLoS One 17(3), e0264974 (2022).

    2. Monfeuga, T., Norlin, J., Bugge, A., et al. Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients. Mol. Metab. 79, 101850 (2024).