An inhibitor of VPS34
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VPS34-IN-19

Item No. 41357

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4′-(cyclopropylmethyl)-2-(4-pyridinylamino)[4,5′-bipyrimidin]-2′-yl]amino]-2-methyl-2-propanol
CAS Number
1383716-46-8
Synonyms
  • Compound 19
  • Vacuolar Protein Sorting 34 Inhibitor 19
  • VPS Inhibitor 19
Molecular Formula
C21H25N7O
Formula Weight
391.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(C)(O)CNC1=NC(CC2CC2)=C(C=N1)C3=NC(NC4=CC=NC=C4)=NC=C3
InChi Code
InChI=1S/C21H25N7O/c1-21(2,29)13-25-19-24-12-16(18(28-19)11-14-3-4-14)17-7-10-23-20(27-17)26-15-5-8-22-9-6-15/h5-10,12,14,29H,3-4,11,13H2,1-2H3,(H,24,25,28)(H,22,23,26,27)
InChi Key
XJTIGGCBXFIZJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    Product Description

    VPS34-IN-19 is an inhibitor of the class III phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (VPS34; IC50 = 15 nM).1 It is selective for VPS34 over PI3Kδ (IC50 = 802 nM) and PI3Kα, PI3Kβ, and PI3Kγ (IC50s = >802 nM for all). VPS34-IN-19 (50 mg/kg twice per day) increases the level of intratumoral LC3-II, a marker of reduced autophagy, but does not reduce tumor volume in an RKO colon cancer mouse xenograft model. It also reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in isolated human lung tissue when used at concentrations of 2.5 and 5 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Honda, A., Harrington, E., Cornella-Taracido, I., et al. Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo. ACS Med. Chem. Lett. 7(1), 72-76 (2015).

    2. Yuen, C.-K., Wong, W.-M., Mak, L.-F., et al. Suppression of SARS-CoV-2 infection in ex-vivo human lung tissues by targeting class III phosphoinositide 3-kinase. J. Med. Virol. 93(4), 2076-2083 (2021).