A Tie2 inhibitor
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BAY-826

Item No. 41365

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluoro-sulfur
CAS Number
1448316-08-2
Synonyms
  • BAY-Tie2
  • BAY-Tunica Interna Endothelial Cell Kinase 2
Molecular Formula
C26H19F5N6OS
Formula Weight
558.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=C(C=C(N2C=CN3N=C(C4=CC=CN=C4)C=C32)C(C)=C1)NC(C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5)=O
InChi Code
InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)
InChi Key
MPASHPJAIUOWCK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    BAY-826 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2; IC50 = 0.5 nM).1 It inhibits Tie2 autophosphorylation in human umbilical vein endothelial cells (HUVECs; EC50 = 1.3 nM).2 BAY-826 (0.1 or 1 µM), in combination with radiation, reduces colony formation in a colony formation assay using SMA-497, SMA-540, SMA-560, and GL261 mouse glioma cells. In vivo, BAY 826 (100 mg/kg per day), in combination with radiation, decreases tumor volume and vascularization, as well as increases the number of CD45+ T cell tumor infiltrates and animal survival in an SMA-560 murine glioma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sübmeier, F., Lobell, M., Grünewald, S., et al. Sustituted phenylimidazopyrazoles and their use. (2013).

    2. Schneider, H., Szabo, E., Machado, R.A.C., et al. Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J. Neurochem. 140(1), 170-182 (2016).