A PI4KIIIα inhibitor
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GSK-F1

Item No. 41366

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulfonamide
CAS Number
1402345-92-9
Molecular Formula
C27H18F5N5O4S
Formula Weight
603.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1C2=C(N=C(N1C3=C(C=CC=C3)C(F)(F)F)N)C=CC(C4=CC(S(=O)(NC5=CC=C(C=C5F)F)=O)=C(OC)N=C4)=C2
InChi Code
InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35)
InChi Key
MSRFVAYVUUHQCN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    GSK-F1 is a PI4KIIIα inhibitor (IC50 = 5.01 nM).1 It is selective for PI4KIIIα over PI4Kβ, PI3Kα, PI3Kβ, PI3Kδ, and PI4Kγ (IC50s = 1,000, 2,512, 7,943, 2,512, and 2,512 nM, respectively). GSK-F1 inhibits the replication of hepatitis C virus (HCV) genotypes 1a, 1b, and 2a in a cell-based replicon assay (IC50s = 12.6, 2.51, and 12.6 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leivers, A.L., Tallant, M., Shotwell, J.B., et al. Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents. J. Med. Chem. 57(5), 2091-2106 (2014).