An ionizable cationic lipid
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DMT7

Item No. 41389

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea
CAS Number
3080542-12-4
Molecular Formula
C42H79N3S
Formula Weight
658.2
Purity
≥90%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCCCCC/C=C\C/C=C\CCCCC)NC(NCCN(C)C)=S
InChi Code
InChI=1S/C42H79N3S/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-41(44-42(46)43-39-40-45(3)4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-4H3,(H2,43,44,46)/b15-13-,16-14-,21-19-,22-20
InChi Key
KEVKDMPMVGLRPK-KWXKLSQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

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    10 mg

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    Product Description

    DMT7 is an ionizable cationic lipid (pKa= 6.5) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and anticancer agents in vivo.1 LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and the STING agonist MSA-2 (Item No. 30140) decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis. The same LNPs decrease the number of tumor-associated regulatory T cells (Tregs), increase the number of tumor-associated M1 macrophages, and increase intratumoral levels of Il-12, Il-2, Tnf-α, and Ifn-γ in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, B., Tang, M., Chen, Q., et al. Delivery of mRNA encoding interleukin-12 and a stimulator of interferon genes agonist potentiates antitumor efficacy through reversing T cell exhaustion. ACS Nano 18(24), 15499-15516 (2024).