A derivative of lithocholic acid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N-butyl Lithocholic Acid

Item No. 41397

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β)-3-hydroxy-cholan-24-oic acid, butyl ester
CAS Number
135013-42-2
Synonyms
  • N-butyl LCA
  • N-butyl Lithocholate
Molecular Formula
C28H48O3
Formula Weight
432.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
C[C@H](CCC(OCCCC)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C28H48O3/c1-5-6-17-31-26(30)12-7-19(2)23-10-11-24-22-9-8-20-18-21(29)13-15-27(20,3)25(22)14-16-28(23,24)4/h19-25,29H,5-18H2,1-4H3/t19-,20-,21-,22+,23-,24+,25+,27+,28-/m1/s1
InChi Key
DVARNCCRARJWLO-WQKHHYSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $39

    Add

    5 mg

    $126

    Add

    10 mg

    $231

    Add

    25 mg

    $482

    Add
    Cayman Chemical
    Visit Our Lipid Nanoparticle Resource Center for Additional Tools & Resources
    EXPLORE NOW
    Product Description

    N-butyl Lithocholic acid is a derivative of the secondary bile acid lithocholic acid (Item No. 20253).1 Lipid nanoparticles (LNPs) containing N-butyl lithocholic acid and encapsulating an mRNA vaccine expressing influenza hemagglutinin exhibit less heart, spleen, and liver toxicity than LNPs containing cholesterol (Item Nos. 9003100 | 39088) in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bae, S.-H., Yoo, S., Lee, J., et al. A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety. Bioact. Mater. 38, 486-498 (2024).