A serine/threonine protein kinase N3 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PKN3 Inhibitor Compound 16

Item No. 41437

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-iodo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine
CAS Number
2361545-75-5
Synonyms
  • Protein Kinase N3 Inhibitor Compound 16
Molecular Formula
C18H17IN2O3
Formula Weight
436.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
IC1=CC2=NC=CC(NC3=CC(OC)=C(OC)C(OC)=C3)=C2C=C1
InChi Code
InChI=1S/C18H17IN2O3/c1-22-16-9-12(10-17(23-2)18(16)24-3)21-14-6-7-20-15-8-11(19)4-5-13(14)15/h4-10H,1-3H3,(H,20,21)
InChi Key
ZGFLIBPJHOZGNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $159

    Add

    10 mg

    $282

    Add

    25 mg

    $616

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    PKN3 inhibitor compound 16 is an inhibitor of serine/threonine protein kinase N3 (IC50 = 14 nM).1 It is selective for this kinase over a panel of 234 kinases but does inhibit serine/threonine protein kinase NLK, activin receptor type 1 (ACTR1), and receptor-interacting serine/threonine kinase 2 (RIPK2) at 1 µM, as well as cyclin G-associated kinase (GAK; IC50 = 74 nM in a bioluminescence resonance energy transfer (BRET) assay).1,2 PKN3 inhibitor compound 16 inhibits viral replication in dengue virus-infected Huh7 cells (EC50 = 3.6 µM) without inducing cell death with a 50% cytotoxic concentration (CC50) value of >10 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Asquith, C.R.M., Temme, L., East, M.P., et al. Identification of 4-anilinoquin(az)oline as a cell-active protein kinase novel 3 (PKN3) inhibitor chemotype. ChemMedChem 17(12), e202200161 (2022).

    2. Asquith, C.R.M., Laitinen, T., Bennett, J.M., et al. Design and analysis of the 4-anilinoquin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure-activity relationships. ChemMedChem 15(1), 26-49 (2020).

    3. Saul, S., Pu, S.-Y., Zuercher, W.J., et al. Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines. Bioorg. Med. Chem. Lett. 30(16), 127284 (2020).