A covalent inhibitor of cereblon
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EM12-SO2F

Item No. 41446

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
CAS Number
2803819-61-4
Molecular Formula
C13H11FN2O5S
Formula Weight
326.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1NC(C(CC1)N2C(C3=CC(S(=O)(F)=O)=CC=C3C2)=O)=O
InChi Code
InChI=1S/C13H11FN2O5S/c14-22(20,21)8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
InChi Key
IAJNULNMWPZFDR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

    $141

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    25 mg

    $310

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    50 mg

    $537

    Add
    Cayman Chemical
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    Product Description

    EM12-SO2F is a covalent inhibitor of cereblon (CRBN; IC50 = 0.88 nM).1 It inhibits the degradation of Ikaros family zinc finger protein 1 (IKZF1) induced by the thalidomide derivative lenalidomide (Item No. 14643) in MOLT-4 lymphoblasts when used at a concentration of 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cruite, J.T., Dann, G.P., Che, J., et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem. Biol. 3(9), 1105-1110 (2022).