An AMPK inhibitor
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BAY-3827

Item No. 41448

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl-benzamide
CAS Number
2377576-35-5
Molecular Formula
C27H25FN6O
Formula Weight
468.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
N#CC1=C(C)N(C)C(C)=C(C1C2=CC3=C(C(C)=C2F)NN=C3NC(C4=C(C=CC=C4)CC)=O)C#N
InChi Code
InChI=1S/C27H25FN6O/c1-6-17-9-7-8-10-18(17)27(35)31-26-20-11-19(24(28)14(2)25(20)32-33-26)23-21(12-29)15(3)34(5)16(4)22(23)13-30/h7-11,23H,6H2,1-5H3,(H2,31,32,33,35)
InChi Key
OZFFKOSQNBBYCA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    BAY-3827 is an inhibitor of AMP-activated protein kinase (AMPK; IC50 = 1.4 nM at 10 µM ATP).1 It is selective for AMPK over Aurora A kinase, FMS-related tyrosine kinase 3 (FLT3), and c-Met (IC50s = 1,324, 124, and 788 nM, respectively), p90 ribosomal S6 kinase 2 (RSK2), RSK3, RSK4, p90 ribosomal S6 kinase 1 (MSK1), and MST3 (IC50s = 52, 36, 24, 43, and 94 nM, respectively), and a panel of 331 kinases at 10 µM but does inhibit RSK1 (IC50 = 9 nM). BAY-3827 selectively inhibits the proliferation of androgen-dependent LNCaP, VCaP, and 22Rv1 prostate cancer cells (IC50s = 0.28, 1.71, and 5.55 µM, respectively) over androgen receptor-negative C4-2B, PC3, and DU145 prostate cancer cells (IC50s = >10 µM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lemos, C., Schulze, V.K., Baumgart, S.J., et al. The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models. Cell. Oncol. (Dordr) 44(3), 581-594 (2021).