A PPARγ inverse agonist
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FX-909

Item No. 41452

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(5,7-difluoro-1,4-dihydro-4-oxo-2-quinolinyl)-4-(methylsulfonyl)-benzonitrile
CAS Number
2924573-90-8
Molecular Formula
C17H10F2N2O3S
Formula Weight
360.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=C(N2)C=C(F)C=C1F)C=C2C(C=C(C#N)C=C3)=C3S(C)(=O)=O
InChi Code
InChI=1S/C17H10F2N2O3S/c1-25(23,24)16-3-2-9(8-20)4-11(16)13-7-15(22)17-12(19)5-10(18)6-14(17)21-13/h2-7H,1H3,(H,21,22)
InChi Key
RBUBBZVQPHSZEZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $653

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    Cayman Chemical
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    Product Description

    FX-909 is a peroxisome proliferator-activated receptor γ (PPARγ) inverse agonist.1 It inhibits the growth of urothelial cancer cells in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sims, R., Mertz, J.A., Wilson, J.E., et al. Discovery of FX-909, a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor, to potentially treat patients with the luminal subtype of advanced urothelial cancer (UC). Cancer Res. 83(7), (2023).