An endogenous peptide fragment of rat prepro-MCH
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Neuropeptide EI (rat) (trifluoroacetate salt)

Item No. 41457

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-isoleucylglycyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-asparaginyl-L-seryl-L-alanyl-L-lysyl-L-phenylalanyl-L-prolyl-L-isoleucinamide, trifluoroacetate salt
Synonyms
  • NEI
  • Neuropeptide-Glutamic Acid-Isoleucine
Molecular Formula
C63H98N16O23 • XCF3COOH
Formula Weight
1447.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
EIGDEENSAKFPI-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@@H](CCC(O)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@]([C@H](CC)C)([H])C(N)=O)=O)=O)CC2=CC=CC=C2)=O)=O)C)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O
InChi Code
InChI=1S/C63H98N16O23.C2HF3O2/c1-6-31(3)50(52(67)91)77-61(100)43-17-13-25-79(43)63(102)41(26-34-14-9-8-10-15-34)75-55(94)36(16-11-12-24-64)71-53(92)33(5)69-60(99)42(30-80)76-58(97)39(27-44(66)81)74-57(96)38(20-23-48(87)88)72-56(95)37(19-22-47(85)86)73-59(98)40(28-49(89)90)70-45(82)29-68-62(101)51(32(4)7-2)78-54(93)35(65)18-21-46(83)84;3-2(4,5)1(6)7/h8-10,14-15,31-33,35-43,50-51,80H,6-7,11-13,16-30,64-65H2,1-5H3,(H2,66,81)(H2,67,91)(H,68,101)(H,69,99)(H,70,82)(H,71,92)(H,72,95)(H,73,98)(H,74,96)(H,75,94)(H,76,97)(H,77,100)(H,78,93)(H,83,84)(H,85,86)(H,87,88)(H,89,90);(H,6,7)/t31-,32-,33-,35-,36-,37-,38-,39-,40-,41-,42-,43-,50-,51-;/m0./s1
InChi Key
FABCGLFXCFXXIX-VXNMOIOASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Neuropeptide EI (NEI) is an endogenous peptide fragment of rat prepro-melanin concentrating hormone (MCH) that is involved in hormone release, grooming behavior, and motor activity.1 NEI corresponds to amino acids 140-152 of rat prepro-MCH and 131-143 of human, mouse, and rat prepro-MCH. It is expressed in both the central and peripheral nervous systems, localizes to the cytoplasm, and colocalizes with MCH in the CNS.1,2 NEI (1 µM) reduces thyrotropin-releasing hormone (TRH) release in mediobasal hypothalamus explants.3 Intracerebroventricular administration of NEI increases serum levels of luteinizing hormone (LH) in male rats and in chronically ovariectomized female rats that received estradiol benzoate and progesterone in addition to NEI.4 NEI (1 µg/animal, i.c.v.) induces excessive grooming behavior and increases locomotor activity in rats, effects that can be blocked by MCH (Item No. 24462) or α-melanocyte-stimulating hormone (α-MSH; Item No. 29923).5 It also increases the amount of time spent in REM sleep in rats when injected intracerebroventricularly or into the ventrolateral periaqueductal grey (vlPAG).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bittencourt, J., and Celis, M.E. Anatomy, function and regulation of neuropeptide EI (NEI). Peptides 29(8), 1441-1450 (2008).

    2. Bittencourt, J.C. Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain. Gen. Comp. Endocrinol. 172(2), 185-197 (2011).

    3. Kennedy, A.R., Todd, J.F., Stanley, S.A., et al. Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release, in vivo and in vitro, via the hypothalamus and the pituitary. Endocrinology 42(7), 3265-3268 (2001).

    4. Attademo, A.M., Sánchez-Borzone, M., Lasaga, M., et al. Intracerebroventricular injection of neuropeptide EI increases serum LH in male and female rats. Comparative Study 25(11), 1995-1999 (2004).

    5. Sanchez, M., Baker, B.I., and Celis, M. Melanin-concentrating hormone (MCH) antagonizes the effects of α-MSH and neuropeptide E-I on grooming and locomotor activities in the rat. Peptides 18(3), 393-396 (1997).