A CCR1 antagonist
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BI-639667

Item No. 41523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-fluorophenyl)-N-[1-[2-(methylsulfonyl)-4-pyridinyl]cyclopropyl]-1H-pyrazolo[3,4-c]pyridine-4-carboxamide
CAS Number
1295298-26-8
Molecular Formula
C22H18FN5O3S
Formula Weight
451.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
FC1=CC=C(N2C(C=NC=C3C(NC4(CC4)C5=CC(S(C)(=O)=O)=NC=C5)=O)=C3C=N2)C=C1
InChi Code
InChI=1S/C22H18FN5O3S/c1-32(30,31)20-10-14(6-9-25-20)22(7-8-22)27-21(29)18-11-24-13-19-17(18)12-26-28(19)16-4-2-15(23)3-5-16/h2-6,9-13H,7-8H2,1H3,(H,27,29)
InChi Key
PXQATVYJKMMHAU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    BI-639667 is a chemokine (C-C motif) receptor 1 (CCR1) antagonist.1 It inhibits calcium flux induced by chemokine (C-C motif) ligand 3 (CCL3) in cells expressing CCR1 (IC50 = 2 nM). BI-639667 also inhibits RANTES-induced chemotaxis in THP-1 cells (IC50 = 2 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harcken, C., Kuzmich, D., Cook, B., et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Biooorg. Med. Chem. Lett. 29(3), 441-448 (2019).