An MC4R antagonist
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MCL0020 (trifluoroacetate salt)

Item No. 41544

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-L-alaninamide, trifluoroacetate salt
Synonyms
  • Ac-D-2Nal-Arg-2-Nal-NH2
Molecular Formula
C34H39N7O4 • XCF3COOH
Formula Weight
609.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC1=CC(C=CC=C2)=C2C=C1)=O)[C@H](NC(C)=O)CC3=CC(C=CC=C4)=C4C=C3.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C34H39N7O4.C2HF3O2/c1-21(42)39-30(20-23-13-15-25-8-3-5-10-27(25)18-23)33(45)40-28(11-6-16-38-34(36)37)32(44)41-29(31(35)43)19-22-12-14-24-7-2-4-9-26(24)17-22;3-2(4,5)1(6)7/h2-5,7-10,12-15,17-18,28-30H,6,11,16,19-20H2,1H3,(H2,35,43)(H,39,42)(H,40,45)(H,41,44)(H4,36,37,38);(H,6,7)/t28-,29-,30+;/m0./s1
InChi Key
WEXBUXCORWLODB-UIPQRRKWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $108

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    5 mg

    $486

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    10 mg

    $863

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    25 mg

    $1,348

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    Product Description

    MCL0020 is a melanocortin receptor 4 (MC4R) antagonist.1 It selectively inhibits [Nle4,D-Phe7]-α-MSH (Item No. 24475) binding to recombinant human MC4R over MC1R and MC3R (IC50s = 11.63, >10,000, and 1,115 nM, respectively). MCL0020 (0.1-100 µM) inhibits α-MSH-induced cAMP production in COS-1 cells expressing human MC4R. In vivo, MCL0020 (10 µg/animal; i.c.v.) reduces stress-induced decreases in the time spent in the light area of the light/dark exploration test, indicating anxiolytic-like activity, in mice. It also reverses restraint stress-induced decreases in food intake in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chaki, S., Ogawa, S.-i., Toda, Y., et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur. J. Pharmacol. 474(1), 95-101 (2003).