A peptide fragment of ACTH and an antagonist of MC2R
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ACTH (7-38) (human) (trifluoroacetate salt)

Item No. 41547

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
31-L-serine-α7-38-corticotropin (swine), trifluoroacetate salt
Synonyms
  • Adrenocorticotropic Hormone (7-38)
  • α7-38-ACTH
  • CIP
  • Corticotropin Inhibitory Peptide
Molecular Formula
C167H257N47O46 • XCF3COOH
Formula Weight
3659.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
FRWGKPVGKKRRPVKVYPNGAEDESAEAFPLE-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(NCC(N[C@@H](CCCCN[H])C(N3CCC[C@H]3C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N4CCC[C@H]4C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@H](CC5=CC=C(O[H])C=C5)C(N6CCC[C@H]6C(N[C@@H](CC(N[H])=O)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N7CCC[C@H]7C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CC(C)C)=O)=O)CC8=CC=CC=C8)=O)C)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](N[H])CC9=CC=CC=C9.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C167H257N47O46.C2HF3O2/c1-87(2)75-113(150(245)200-112(164(259)260)59-63-131(227)228)203-153(248)120-48-31-73-213(120)162(257)117(77-95-37-16-13-17-38-95)205-138(233)93(11)188-142(237)107(56-60-128(221)222)192-137(232)92(10)189-152(247)119(86-215)207-148(243)109(58-62-130(225)226)197-151(246)116(81-132(229)230)202-147(242)108(57-61-129(223)224)193-136(231)91(9)187-125(218)83-184-141(236)115(80-124(173)217)204-154(249)121-49-32-74-214(121)163(258)118(78-96-52-54-98(216)55-53-96)206-159(254)134(89(5)6)208-149(244)104(43-22-26-66-170)198-158(253)135(90(7)8)210-156(251)123-51-34-72-212(123)161(256)111(47-30-70-182-167(178)179)199-145(240)106(46-29-69-181-166(176)177)196-144(239)103(42-21-25-65-169)195-143(238)102(41-20-24-64-168)190-126(219)85-186-157(252)133(88(3)4)209-155(250)122-50-33-71-211(122)160(255)110(44-23-27-67-171)191-127(220)84-185-140(235)114(79-97-82-183-101-40-19-18-39-99(97)101)201-146(241)105(45-28-68-180-165(174)175)194-139(234)100(172)76-94-35-14-12-15-36-94;3-2(4,5)1(6)7/h12-19,35-40,52-55,82,87-93,100,102-123,133-135,183,215-216H,20-34,41-51,56-81,83-86,168-172H2,1-11H3,(H2,173,217)(H,184,236)(H,185,235)(H,186,252)(H,187,218)(H,188,237)(H,189,247)(H,190,219)(H,191,220)(H,192,232)(H,193,231)(H,194,234)(H,195,238)(H,196,239)(H,197,246)(H,198,253)(H,199,240)(H,200,245)(H,201,241)(H,202,242)(H,203,248)(H,204,249)(H,205,233)(H,206,254)(H,207,243)(H,208,244)(H,209,250)(H,210,251)(H,221,222)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H,259,260)(H4,174,175,180)(H4,176,177,181)(H4,178,179,182);(H,6,7)/t91-,92-,93-,100-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,133-,134-,135-;/m0./s1
InChi Key
XPVLWMIZWOJXCW-LDRBROOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    Product Description

    Adrenocorticotropic hormone (ACTH) (7-38) is a peptide fragment of ACTH (Item No. 24257) and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor.1 It inhibits ACTH-induced corticosterone production in isolated rat adrenal cells when used at concentrations of 0.455 or 4.55 µM. ACTH (7-38) also inhibits angiotensin-converting enzyme 1 (ACE1; IC50 = 750 nM for the dog enzyme).2 It inhibits basal cAMP secretion by isolated rat inner adrenocortical cells when used at a concentration of 1 µM.3 ACTH (7-38) induces hypotension in normotensive dogs (ED50 = 0.109 nmol/kg).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, C.H., Chung, D., Yamashiro, D., et al. Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands. Proc. Natl. Acad. Sci. U.S.A. 75(9), 4306-4309 (1978).

    2. Verma, P.S., Miller, R.L., Taylor, R.E., et al. Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptides. Biochem. Biophys. Res. Commun. 104(4), 1484-1488 (1982).

    3. Mazzocchi, G., Rebuffat, P., Gottardo, L., et al. Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathway. Horm. Metab. Res. 30(5), 241-243 (1998).

    4. Tenner, T.E., Jr., Yang, C.M., Chang, J.K., et al. Pharmacological comparison of bPTH-(1-34) and other hypotensive peptides in the dog. Peptides 1(4), 285-288 (1980).