A peptide hormone
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β-MSH (human)

Item No. 41549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-aspartyl-L-α-glutamylglycyl-L-prolyl-L-tyrosyl-L-arginyl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-seryl-L-prolyl-L-prolyl-L-lysyl-L-aspartic acid
CAS Number
17908-57-5
Synonyms
  • Human β-Melanotropin
  • β-Lipotropin (35-56)
  • β-Melanocyte-stimulating Hormone
Molecular Formula
C118H174N34O35S
Formula Weight
2660.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
AEKKDEGPYRMEHFRWGSPPKD-OH
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
C[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(NCC(N1CCC[C@H]1C(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CN([H])C=N3)C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CC4=CN([H])C5=C4C=CC=C5)C(NCC(N[C@@H](CO[H])C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@@H](CCCCN[H])C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[H]
InChi Code
InChI=1S/C118H174N34O35S/c1-63(122)97(167)135-77(36-39-93(159)160)105(175)137-71(23-8-11-42-119)100(170)136-72(24-9-12-43-120)102(172)147-84(55-95(163)164)111(181)140-76(35-38-92(157)158)98(168)132-60-91(156)150-47-16-28-87(150)112(182)148-81(52-65-31-33-68(154)34-32-65)109(179)138-74(26-14-45-128-117(123)124)101(171)142-79(41-50-188-2)107(177)141-78(37-40-94(161)162)106(176)146-83(54-67-58-127-62-133-67)110(180)144-80(51-64-19-4-3-5-20-64)108(178)139-75(27-15-46-129-118(125)126)103(173)145-82(53-66-57-130-70-22-7-6-21-69(66)70)99(169)131-59-90(155)134-86(61-153)114(184)152-49-18-30-89(152)115(185)151-48-17-29-88(151)113(183)143-73(25-10-13-44-121)104(174)149-85(116(186)187)56-96(165)166/h3-7,19-22,31-34,57-58,62-63,71-89,130,153-154H,8-18,23-30,35-56,59-61,119-122H2,1-2H3,(H,127,133)(H,131,169)(H,132,168)(H,134,155)(H,135,167)(H,136,170)(H,137,175)(H,138,179)(H,139,178)(H,140,181)(H,141,177)(H,142,171)(H,143,183)(H,144,180)(H,145,173)(H,146,176)(H,147,172)(H,148,182)(H,149,174)(H,157,158)(H,159,160)(H,161,162)(H,163,164)(H,165,166)(H,186,187)(H4,123,124,128)(H4,125,126,129)/t63-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-/m0/s1
InChi Key
XLLJFSCSXTYVTN-UPWOUFKKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    β-Melanocyte-stimulating hormone (β-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland.1,2 It selectively binds to melanocortin receptor 1 (MC1R) over MC3R, MC4R, and MC5R (Kis = 0.89, 10.64, 8.18, and 76.9 nM, respectively).3 β-MSH (1 µM) induces lipolysis in isolated rabbit adipocytes.2 It increases plasma levels of glucagon, insulin, and free fatty acids in fed or fasted rabbits when administered at a dose of 45 µg/animal.4 Cerebrospinal fluid (CSF) levels of β-MSH are increased in patients with restless legs syndrome with painful symptoms.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abe, K., Nicholson, W.E., Little, G.W., et al. Radioimmunoassay of beta-MSH in human plasma and tissues. J. Clin. Invest. 46(10), 1609-1616 (1967).

    2. Richter, W.O., and Schwandt, P. Lipolytic potency of proopiomelanocorticotropin peptides in vitro. Neuropeptides 9(1), 59-74 (1987).

    3. Mayer, J.P., Hsiung, H.M., Flora, D.B., et al. Discovery of a β-MSH-derived MC-4R selective agonist. J. Med. Chem. 48(9), 3095-3098 (2005).

    4. Knudtzon, J. Alpha-melanocyte stimulating hormone increases plasma levels of glucagon and insulin in rabbits. Life Sci. 34(6), 547-554 (1984).

    5. Koo, B.B., Abdelfattah, A., Eysa, A., et al. The melanocortin and endorphin neuropeptides in patients with restless legs syndrome. Ann. Neurol. 95(4), 688-699 (2024).