An MC3R antagonist
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PG-106 (trifluoroacetate salt)

Item No. 41553

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-norleucyl-L-α-aspartyl-β-alanyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2→7)-lactam, trifluoroacetate salt
Synonyms
  • Ac-Nle-c[Asp-βAla-DNal(2′)-Arg-Trp-Lys]-NH2
Molecular Formula
C51H69N13O9 • XCF3COOH
Formula Weight
1008.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@@H](CCCCNC(C[C@@H](C(NCCC(N[C@@H](C(N[C@H]1CCCNC(N)=N)=O)CC(C=C2)=CC3=C2C=CC=C3)=O)=O)NC([C@H](CCCC)NC(C)=O)=O)=O)C(N)=O)[C@H](CC4=CNC5=CC=CC=C54)NC1=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C51H69N13O9.C2HF3O2/c1-3-4-15-38(59-30(2)65)47(70)64-42-28-44(67)55-22-10-9-17-37(45(52)68)61-50(73)41(27-34-29-58-36-16-8-7-14-35(34)36)63-48(71)39(18-11-23-57-51(53)54)62-49(72)40(60-43(66)21-24-56-46(42)69)26-31-19-20-32-12-5-6-13-33(32)25-31;3-2(4,5)1(6)7/h5-8,12-14,16,19-20,25,29,37-42,58H,3-4,9-11,15,17-18,21-24,26-28H2,1-2H3,(H2,52,68)(H,55,67)(H,56,69)(H,59,65)(H,60,66)(H,61,73)(H,62,72)(H,63,71)(H,64,70)(H4,53,54,57);(H,6,7)/t37-,38-,39-,40+,41-,42-;/m0./s1
InChi Key
INSWYMMBLAZFBE-YVBXOHQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $55

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    5 mg

    $248

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    10 mg

    $330

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    25 mg

    $481

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    Product Description

    PG-106 is a cyclic peptidomimetic antagonist of melanocortin receptor 3 (MC3R; IC50 = 210 nM).1 It is selective for MC3R over MC4R and MC5R at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grieco, P., Cai, M., Han, G., et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides 28(6), 1191-1196 (2007).