A peptide MC4R agonist
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RO27-3225 (trifluoroacetate salt)

Item No. 41558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-oxobutyl)-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-N2-methyl-glycinamide, trifluoroacetate salt
CAS Number
1373926-49-8
Synonyms
  • Oxobutyl-His-Phe-Arg-Trp-{Sar}-NH2
Molecular Formula
C39H52N12O6 • XCF3COOH
Formula Weight
784.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Oxobutyl-HFRWX-NH2 (X=Sarcosine)
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
OC(C(F)(F)F)=O.CCCC(N[C@@H](CC1=CN=CN1)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N(C)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O
InChi Code
InChI=1S/C39H52N12O6.C2HF3O2/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28;3-2(4,5)1(6)7/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44);(H,6,7)/t29-,30+,31-,32-;/m0./s1
InChi Key
XBNXUPIBUGBMCO-KQQVHNFSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $131

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    10 mg

    $248

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    25 mg

    $550

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R).1 It selectively induces cAMP production in cells expressing human MC4R (EC50 = 0.3 nM) over cells expressing MC1R, MC3R, or MC5R (EC50s = 1.1, 97.9, and 139.4 nM, respectively). In vivo, RO27-3225 (3, 5, and 10 nmol/animal) reduces food intake in rats, as well as in obese db/db mice when administered at a dose of 200 µg/animal. RO27-3225 also reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal Il-1β and Tnf-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benoit, S.C., Schwartz, M.W., Lachey, J.L., et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J. Neurosci. 20(9), 3442-3448 (2000).

    2. Liu, D., Zhang, H.-G., Zhao, Z.-A., et al. Melanocortin MC4 receptor agonists alleviate brain damage in abdominal compartment syndrome in the rat. Neuropeptides 49, 55-61 (2015).