An IP6K1 and IP6K2 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

UNC7467

Item No. 41597

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[1,1′-biphenyl]-4-yl-2,1-benzisoxazole-5-carboxylic acid
CAS Number
2922283-43-8
Molecular Formula
C20H13NO3
Formula Weight
315.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C1=CC2=C(ON=C2C=C1)C3=CC=C(C=C3)C4=CC=CC=C4)=O
InChi Code
InChI=1S/C20H13NO3/c22-20(23)16-10-11-18-17(12-16)19(24-21-18)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12H,(H,22,23)
InChi Key
FGCSKRKOSIKUGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $65

    Add

    10 mg

    $117

    Add

    25 mg

    $260

    Add

    50 mg

    $488

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    UNC7467 is an inhibitor of inositol hexakisphosphate kinase 1 (IP6K1) and IP6K2 (IC50s = 8.9 and 4.9 nM, respectively).1 It is selective for IP6K1 and IP6K2 over IP6K3 and inositol-triphosphate 3-kinase A (ITPKA; IC50s = 1,320 and 832 nM, respectively), as well as a panel of 30 other kinases at 1 µM, but does inhibit inositol phosphate multi-kinase (IPMK; IC50 = 24.4 nM). In vivo, UNC7467 (5 mg/kg per day) reduces body weight, fat mass, epididymal- and inguinal-adipose tissue deposit weights, and liver weight, as well as blood glucose levels in a pyruvate tolerance test after four weeks, in a mouse model of diet-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, Y., Mukherjee, S., Huang, D., et al. Development of novel IP6K inhibitors for the treatment of obesity and obesity-induced metabolic dysfunctions. J. Med. Chem. 65(9), 6869-6887 (2022).