A USP8 inhibitor
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USP8-IN-1

Item No. 41598

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-amino-4-methoxyphenyl)-N-(4-nitrophenyl)-1-piperazinecarbothioamide
CAS Number
2477650-96-5
Synonyms
  • DC-U43-10
  • Ubiquitin-specific Protease 8 Inhibitor 1
  • USP8 Inhibitor 1
Molecular Formula
C18H21N5O3S
Formula Weight
387.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
S=C(N1CCN(CC1)C2=CC=C(C=C2N)OC)NC(C=C3)=CC=C3[N+]([O-])=O
InChi Code
InChI=1S/C18H21N5O3S/c1-26-15-6-7-17(16(19)12-15)21-8-10-22(11-9-21)18(27)20-13-2-4-14(5-3-13)23(24)25/h2-7,12H,8-11,19H2,1H3,(H,20,27)
InChi Key
LYQOAIJZQPUZEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $244

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    10 mg

    $351

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    Product Description

    USP8-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8; IC50 = 2.6 µM).1 It is selective for USP8 over USP7 (IC50 = >20 µM). USP8-IN-1 inhibits colony formation by H1975 non-small cell lung cancer (NSCLC) cells (IC50 = 30.8 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, J., Tian, Y., Yu, L., et al. Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening. Bioorg. Chem. 101, 103962 (2020).