A USP8 inhibitor
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USP8-IN-3

Item No. 41600

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-nitrophenyl)-N′-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-thiourea
CAS Number
2477651-10-6
Synonyms
  • Ubiquitin-specific Protease 8-IN-3
  • Ubiquitin-specific Protease 8 Inhibitor 3
  • USP 8 Inhibitor 3
Molecular Formula
C18H18F3N5O2S
Formula Weight
425.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
S=C(NC1CCN(CC1)C2=CC=CC(C(F)(F)F)=N2)NC(C=C3)=CC=C3[N+]([O-])=O
InChi Code
InChI=1S/C18H18F3N5O2S/c19-18(20,21)15-2-1-3-16(24-15)25-10-8-13(9-11-25)23-17(29)22-12-4-6-14(7-5-12)26(27)28/h1-7,13H,8-11H2,(H2,22,23,29)
InChi Key
DYHHEFBWFATDAN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Product Description

    USP8-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8; IC50 = 4 µM).1 It inhibits the growth of H1975 non-small cell lung cancer (NSCLC) and GH3 rat pituitary cells (GI50s = 6.01 and 37.03 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Z., Luo, C., Bian, J., et al. Preparing method and application of USP8 inhibitor. (2020).