A polyphenol with diverse biological activities
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Hydroxytyrosol Acetate

Item No. 41665

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(acetyloxy)ethyl]-1,2-benzenediol
CAS Number
69039-02-7
Synonyms
  • HT-AC
  • HTy-Ac
Molecular Formula
C10H12O4
Formula Weight
196.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C)OCCC1=CC=C(C(O)=C1)O
InChi Code
InChI=1S/C10H12O4/c1-7(11)14-5-4-8-2-3-9(12)10(13)6-8/h2-3,6,12-13H,4-5H2,1H3
InChi Key
FGJGLFPNIZXRLV-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $28

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    50 mg

    $110

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    100 mg

    $193

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    250 mg

    $413

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    Product Description

    Hydroxytyrosol acetate is a polyphenol that has been found in O. europaea and has diverse biological activities.1,2,3,4 It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 1.73 µM).1 Hydroxytyrosol acetate is active against V. parahaemolyticus (MIC = 39 µg/ml).2 It inhibits LPS-induced increases in nitric oxide (NO), inducible nitric oxide synthase (iNOS), and COX-2 levels in isolated mouse peritoneal macrophages when used at concentrations of 50 or 100 µM.1 Hydroxytyrosol acetate (1-100 µM) inhibits hypoxia- and reoxygenation-induced lactate dehydrogenase (LDH) release in isolated rat brain slices.3 Dietary administration of hydroxytyrosol acetate (0.05%) inhibits paw swelling, joint synovial hyperplasia, and cartilage erosion in a mouse model of collagen II-induced rheumatoid arthritis.4 It decreases serum levels of IgG1, IgG2a, matrix metalloproteinase-3 (MMP-3), and cartilage oligomeric matrix protein (COMP), as well as levels of TNF-α, IL-1β, IFN-γ, IL-6, IL-17a, and prostaglandin E2 (PGE2; Item No. 14010) in hind paw joint homogenates, in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aparicio-Soto, M., Sánchez-Fidalgo, S., González-Benjumea, A., et al. Naturally occurring hydroxytyrosol derivatives: Hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplements. J. Agric. Food Chem. 63(3), 836-846 (2015).

    2. Wei, J., Wang, S., Pei, D., et al. Antibacterial activity of hydroxytyrosol acetate from olive leaves (Olea Europaea L.). Nat. Prod. Res. 32(16), 1967-1970 (2018).

    3. González-Correa, J.A., Navas, M.D., Lopez-Villodres, J.A., et al. Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia-reoxygenation. Neurosci. Lett. 446(2-3), 143-146 (2008).

    4. Rosillo, M.A., Sánchez-Hidalgo, M., González-Benjumea, A., et al. Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis. Mol. Nutr. Food Res. 59(12), 2537-2546 (2015).