An androgen receptor N-terminal transactivation domain inhibitor
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Masofaniten

Item No. 41670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[4-[1-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]-1-methylethyl]phenoxy]methyl]-2-pyrimidinyl]-methanesulfonamide
CAS Number
2416716-62-4
Synonyms
  • EPI-7386
Molecular Formula
C24H24Cl2N4O4S
Formula Weight
535.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
N#CC1=CC(C(C)(C)C2=CC=C(C=C2)OCC3=NC(NS(=O)(C)=O)=NC=C3)=CC(Cl)=C1OCCCl
InChi Code
InChI=1S/C24H24Cl2N4O4S/c1-24(2,18-12-16(14-27)22(21(26)13-18)33-11-9-25)17-4-6-20(7-5-17)34-15-19-8-10-28-23(29-19)30-35(3,31)32/h4-8,10,12-13H,9,11,15H2,1-3H3,(H,28,29,30)
InChi Key
GVCZSODXLFBYSS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $118

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    5 mg

    $471

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    10 mg

    $824

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    Product Description

    Masofaniten is an androgen receptor N-terminal transactivation domain inhibitor (ARTADI).1 It binds to the tryptophan residues in positions 397 (W397) and W433 in the AR TAD.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Obst, J.K., Tien, A.H., Setiawan, J.C., et al. Inhibitors of the transactivation domain of androgen receptor as a therapy for prostate cancer. Steroids 210, 109482 (2024).