An eIF2B activator
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DNL343

Item No. 41674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-chlorophenoxy)-N-[3-[5-[cis-3-(trifluoromethoxy)cyclobutyl]-1,3,4-oxadiazol-2-yl]bicyclo[1.1.1]pent-1-yl]-acetamide
CAS Number
2278265-85-1
Molecular Formula
C20H19ClF3N3O4
Formula Weight
457.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1(C2)CC2(C1)C3=NN=C([C@H]4C[C@@H](OC(F)(F)F)C4)O3)COC5=CC=C(Cl)C=C5
InChi Code
InChI=1S/C20H19ClF3N3O4/c21-12-1-3-13(4-2-12)29-7-15(28)25-19-8-18(9-19,10-19)17-27-26-16(30-17)11-5-14(6-11)31-20(22,23)24/h1-4,11,14H,5-10H2,(H,25,28)/t11-,14+,18?,19?
InChi Key
IKPNRMYDOSNVAU-QEJBIBHGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $94

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    5 mg

    $422

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    10 mg

    $748

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    25 mg

    $1,637

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    Product Description

    DNL343 is an activator of eukaryotic translation initiation factor 2B (eIF2B; IC50 = 9.8 nM in a reporter assay) and a derivative of 2BAct (Item No. 37788).1 It inhibits sodium arsenite-induced formation of stress granules positive for TAR DNA-binding protein 43 (TDP-43) in an in vitro model of amyotrophic lateral sclerosis (ALS) using H4 cells (IC50 = 12.46 nM). DNL343 (50 mg/kg) decreases the expression of integrated stress response (ISR) genes in Eif2b5R191H mutant mice in a model of neurodegeneration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Craig, R.A.I., De Vicente, J., Estrada, A.A., et al. Discovery of DNL343: A potent, selective, and brain-penetrant eIF2B activator designed for the treatment of neurodegenerative diseases. J. Med. Chem. 67(7), 5758-5782 (2024).