An NSAID and COX inhibitor
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Fenclofenac

Item No. 41709

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,4-dichlorophenoxy)-benzeneacetic acid
CAS Number
34645-84-6
Synonyms
  • RX-67408
Molecular Formula
C14H10Cl2O3
Formula Weight
297.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
ClC1=CC(Cl)=CC=C1OC2=C(CC(O)=O)C=CC=C2
InChi Code
InChI=1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18)
InChi Key
IDKAXRLETRCXKS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $125

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    10 mg

    $220

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    25 mg

    $482

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    Product Description

    Fenclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 7 and 4 µM for COX-1 and COX-2, respectively).1,2 It reduces paw volume in a rat model of adjuvant-induced polyarthritis when administered at doses of 3, 15, and 75 mg/kg and reverses yeast-induced motor impairments, a measure of nociception, in rats (ED50 = 54.3 mg/kg).1 Fenclofenac (20-180 mg/kg) reduces carrageenan-induced paw edema in rats. Formulations containing fenclofenac have previously been used in the treatment of rheumatoid arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Atkinson, D.C., and Leach, E.C. Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac). Agents Actions 6(5), 657-666 (1976).

    2. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).