An LHR antagonist
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BAY-899

Item No. 41716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide
CAS Number
2471967-92-5
Molecular Formula
C25H19F2N5O2
Formula Weight
459.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC1=CC=C([C@H]2C3=CC=CN=C3CCN2C(NC4=CN=C(N=C4)OC5=CC=C(F)C=C5)=O)C=C1
InChi Code
InChI=1S/C25H19F2N5O2/c26-17-5-3-16(4-6-17)23-21-2-1-12-28-22(21)11-13-32(23)25(33)31-19-14-29-24(30-15-19)34-20-9-7-18(27)8-10-20/h1-10,12,14-15,23H,11,13H2,(H,31,33)/t23-/m0/s1
InChi Key
VKQBTIMLSDGNLG-QHCPKHFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $98

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    10 mg

    $186

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    25 mg

    $416

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    50 mg

    $686

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    Product Description

    BAY-899 is an antagonist of the luteinizing hormone receptor (LHR; IC50s = 185 and 46 nM for the human and rat receptors, respectively).1 It is selective for LHR over thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) receptors (IC50s = 24 and >16 µM, respectively, for the human receptors) and a panel of 25 G protein-coupled receptors (GPCRs) at 10 µM. BAY-899 (12.5 mg/kg per day) reduces serum levels of estradiol in female rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wortmann, L., Lindenthal, B., Muhn, P., et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-based, potent, and selective antagonists of the luteinizing hormone receptor which reduce sex hormone levels in vivo. J. Med. Chem. 62(22), 10321-10341 (2019).