An α1-adrenergic and 5-HT2A receptor antagonist
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MT-1207 (hydrochloride)

Item No. 41720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1H-benzotriazole, monohydrochloride
CAS Number
1610794-70-1
Molecular Formula
C21H24N6S • HCl
Formula Weight
429.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
N1(N=NC2=C1C=CC=C2)CCCCN3CCN(CC3)C4=NSC5=C4C=CC=C5.Cl
InChi Code
InChI=1S/C21H24N6S.ClH/c1-4-10-20-17(7-1)21(23-28-20)26-15-13-25(14-16-26)11-5-6-12-27-19-9-3-2-8-18(19)22-24-27;/h1-4,7-10H,5-6,11-16H2;1H
InChi Key
UFMLXCNESJKXFY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $29

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    5 mg

    $137

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    10 mg

    $229

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    50 mg

    $715

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    Product Description

    MT-1207 is an antagonist of α1A-, α1B-, and α1D-adrenergic receptors and the serotonin (5-HT) receptor subtype 5-HT2A (IC50s = <0.1, 0.15, 1.4, and 0.27 nM, respectively).1 It is selective for these receptors over a panel of 87 receptors, ion channels, and enzymes at 1 µM but does inhibit α2A- and α2B-adrenergic and 5-HT1A, 5-HT1B, 5-HT2B, and 5-HT2C receptors (IC50s = 18.1, 4.89, 4.68, 41, 11.5, and 26 nM, respectively), among others. MT-1207 induces relaxation of isolated rat aortic rings precontracted with epinephrine, potassium chloride, norepinephrine, or 5-HT in a concentration-dependent manner. It decreases systolic and diastolic blood pressure and heart rate in spontaneously hypertensive rats and two kidney-one clip (2K-1C) renal hypertensive dogs when administered at doses of 10 and 4 mg/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, T.Y., Wang, P., Tian, J.S., et al. Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent. Acta. Pharmacol. Sin. 42(6), 885-897 (2021).