A P. vivax PI4K inhibitor
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MMV390048

Item No. 41835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[4-(methylsulfonyl)phenyl]-6′-(trifluoromethyl)-[3,3′-bipyridin]-2-amine
CAS Number
1314883-11-8
Molecular Formula
C18H14F3N3O2S
Formula Weight
393.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=S(C1=CC=C(C2=CN=C(C(C3=CN=C(C(F)(F)F)C=C3)=C2)N)C=C1)(C)=O
InChi Code
InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
InChi Key
RTJQABCNNLMCJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $76

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    10 mg

    $121

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    25 mg

    $247

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    50 mg

    $418

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    Product Description

    MMV390048 is an inhibitor of P. vivax PI4K (IC50 = 3.4 nM).1 It is active against P. falciparum (IC50 = 28 nM). MMV390048 decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg). It reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys when administered at a dose of 20 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Paquet, T., Le Manach, C., Cabrera, D.G., et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci. Transl. Med. 9(387), eaad9735 (2017).