An amino acid conjugate and intermediate in isoleucine catabolism
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Isomer(s)
228883-Methylcrotonyl Glycine
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Tiglyl Glycine

Item No. 41836

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2E)-2-methyl-1-oxo-2-buten-1-yl]-glycine
CAS Number
35842-45-6
Synonyms
  • N-Tigloylglycine
Molecular Formula
C7H11NO3
Formula Weight
157.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
OC(CNC(/C(C)=C/C)=O)=O
InChi Code
InChI=1S/C7H11NO3/c1-3-5(2)7(11)8-4-6(9)10/h3H,4H2,1-2H3,(H,8,11)(H,9,10)/b5-3+
InChi Key
WRUSVQOKJIDBLP-HWKANZROSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $39

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    10 mg

    $66

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    50 mg

    $193

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    100 mg

    $270

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    Product Description

    Tiglyl glycine is an amino acid conjugate and intermediate in the catabolism of the amino acid isoleucine.1 It is formed from tiglyl-CoA by glycine-N-acyltransferase. Urinary tiglyl glycine levels are increased in patients with β-ketothiolase deficiency, propionate metabolism disorders, or respiratory chain disorders.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bennett, M.J., Powell, S., Swartling, D.J., et al. Tiglylglycine excreted in urine in disorders of isoleucine metabolism and the respiratory chain measured by stable isotope dilution GC-MS. Clin. Chem. 40(10), 1879-1883 (1994).

    2. Villani, G.R., Gallo, G., Scolamiero, E., et al. "Classical organic acidurias": Diagnosis and pathogenesis. Clin. Exp. Med. 17(3), 305-323 (2017).