An HK4 activator
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AZD 1656

Item No. 41839

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)-benzamide
CAS Number
919783-22-5
Molecular Formula
C24H26N6O5
Formula Weight
478.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CC1=CN=C(NC(C2=CC(O[C@@H](C)COC)=CC(OC3=NC=C(N=C3)C(N4CCC4)=O)=C2)=O)C=N1
InChi Code
InChI=1S/C24H26N6O5/c1-15-10-27-21(12-25-15)29-23(31)17-7-18(34-16(2)14-33-3)9-19(8-17)35-22-13-26-20(11-28-22)24(32)30-5-4-6-30/h7-13,16H,4-6,14H2,1-3H3,(H,27,29,31)/t16-/m0/s1
InChi Key
FJEJHJINOKKDCW-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

    $273

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    10 mg

    $424

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    25 mg

    $832

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AZD 1656 is an activator of hexokinase-4 (HK4).1 It activates HK4 and induces glucose phosphorylation in a cell-free assay (EC50 = 61 nM). AZD 1656 (0.3 mg/kg) decreases blood glucose levels in an oral glucose tolerance test (OGTT) in rats. It reduces blood glucose levels and increases plasma insulin levels in mice when administered at doses of 2, 4.5, or 9 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Waring, M.J., Clarke, D.S., Fenwick, M.D., et al. Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656. MedChemComm 3(9), 1077 (2012).

    2. Ford, B.E., Chachra, S.S., Alshawi, A., et al. Chronic glucokinase activator treatment activates liver carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge. Diabetes Obes. Metab. 22(11), 1985-1994 (2020).