An orexin receptor 2 antagonist
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JNJ-42847922

Item No. 41854

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-methanone
CAS Number
1293281-49-8
Synonyms
  • MIN-202
Molecular Formula
C21H22FN7O
Formula Weight
407.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N1CC(CN(C2=NC(C)=CC(C)=N2)C3)C3C1)C4=C(F)C=CC=C4N5N=CC=N5
InChi Code
InChI=1S/C21H22FN7O/c1-13-8-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)19-17(22)4-3-5-18(19)29-23-6-7-24-29/h3-8,15-16H,9-12H2,1-2H3
InChi Key
SQOCEMCKYDVLMM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $83

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    10 mg

    $132

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    25 mg

    $207

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    50 mg

    $372

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    Product Description

    JNJ-42847922 is an orexin receptor 2 (OX2R) antagonist (Ki = 10 nM for the human receptor).1 It is selective for OX2R over OX1R (Ki = 794 nM for the human receptor) and a panel of 50 receptors, ion channels, and transporters at 1 µM. JNJ-42847922 (3, 10, and 30 mg/kg) reduces the latency to non-rapid eye movement (NREM) sleep onset and increases the duration of NREM sleep in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonaventure, P., Shelton, J., Yun, S., et al. Characterization of JNJ-42847922, a selective orexin-2 receptor antagonist, as a clinical candidate for the treatment of insomnia. J. Pharmacol. Exp. Ther. 354(3), 471-482 (2015).