A USP1 inhibitor
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KSQ-4279

Item No. 41862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-1H-pyrazolo[3,4-d]pyrimidine
CAS Number
2446480-97-1
Synonyms
  • Ubiquitin-specific Protease 1 Inhibitor 1
  • USP1-IN-1
  • USP1 Inhibitor 1
Molecular Formula
C27H25F3N8O
Formula Weight
534.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=NC=NC(C2CC2)=C1C3=NC=C(C=NN4CC5=CC=C(C6=NC(C(F)(F)F)=CN6C(C)C)C=C5)C4=N3
InChi Code
InChI=1S/C27H25F3N8O/c1-15(2)37-13-20(27(28,29)30)35-24(37)18-6-4-16(5-7-18)12-38-25-19(11-34-38)10-31-23(36-25)21-22(17-8-9-17)32-14-33-26(21)39-3/h4-7,10-11,13-15,17H,8-9,12H2,1-3H3
InChi Key
KCBWAFJCKVKYHO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $491

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    10 mg

    $872

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    25 mg

    $1,498

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    Cayman Chemical
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    Product Description

    KSQ-4279 is an inhibitor of ubiquitin-specific protease 1 (USP1; IC50 = 21.1 nM).1 It reduces the viability of H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 500 nM. KSQ-4279 (1 µM) induces cell cycle arrest at the S phase in MDA-MB-436 breast cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, H., Liu, B.J., Xu, J., et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7(8H)-one derivatives as potent USP1 inhibitors. Eur. J. Med. Chem. 275:116568, (2024).