A PPARα agonist and STING inhibitor
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BH400

Item No. 41892

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(((4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)amino)-2-hydroxybenzoic acid
Molecular Formula
C20H16FNO3
Formula Weight
337.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
FC(C=C1)=CC=C1C(C=C2)=CC=C2CNC3=CC=C(O)C(C(O)=O)=C3
InChi Code
InChI=1S/C20H16FNO3/c21-16-7-5-15(6-8-16)14-3-1-13(2-4-14)12-22-17-9-10-19(23)18(11-17)20(24)25/h1-11,22-23H,12H2,(H,24,25)
InChi Key
PEWZEZWZGJQFKN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $310

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    10 mg

    $495

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    Cayman Chemical
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    Product Description

    BH400 is an agonist of peroxisome proliferator-activated receptor α (PPARα) and an inhibitor of stimulator of interferon genes (STING; IC50 = 8.1 µM).1 It induces transactivation of PPARα in a reporter assay using THP-1 cells (EC50 = 1.2 µM). BH400 (10 µM) inhibits decreases in viability induced by 4-hydroxy nonenal (4-HNE; Item No. 32100) or hydrogen peroxide (H2O2) in 661W retinal ganglion cells. It prevents LPS-induced increases in phosphorylated TANK-binding kinase 1 (TBK1) and IL-6 levels and LPS-induced decreases in peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) levels in HMC3 microglial cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, B., Cui, Y., Lee, J.J., et al. Design and assessment of first-generation heterobifunctional PPARα/STING modulators. ACS Med. Chem. Lett. 15(8), 1279-1286 (2024).