An amidine-incorporated degradable lipid
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Lipid 12T-O14

Item No. 41946

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetradecyl 3-((4-((4-decylphenyl)amino)-4-iminobutyl)thio)propanoate
Molecular Formula
C37H66N2O2S
Formula Weight
603.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
N=C(NC1=CC=C(C=C1)CCCCCCCCCC)CCCSCCC(OCCCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C37H66N2O2S/c1-3-5-7-9-11-13-14-15-16-18-20-22-31-41-37(40)30-33-42-32-23-25-36(38)39-35-28-26-34(27-29-35)24-21-19-17-12-10-8-6-4-2/h26-29H,3-25,30-33H2,1-2H3,(H2,38,39)
InChi Key
JHGSICJQTCTZTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $743

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    Cayman Chemical
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    Product Description

    Lipid 12T-O14 is an amidine-incorporated degradable (AID) lipid (pKa = 8.15) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro or in vivo.1 LNPs containing lipid 12T-O14 and encapsulating GFP-targeting siRNA reduce GFP levels in HepG2-GFP cells. Intramuscular delivery of LNPs containing lipid 12T-O14 and encapsulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-encoding mRNA increases anti-SARS-CoV-2 spike protein IgG titers in mice in a prime and boost immunization regimen. LNPs containing lipid 12T-O14 accumulate in the liver, but LNPs containing both lipid 12T-O14 and MC3 (DLin-MC3-DMA; Item No. 34364) can be tuned to target the lungs or the spleen.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, X., Alameh, M.G., Gong, N., et al. Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nat. Chem. 16(10), 1687-1697 (2024).