A PEGylated form of C8 ceramide
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C8 Ceramide-mPEG(2000)

Item No. 41954

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
a-[4-[[(2S,3R,4E)-3-hydroxy-2-[(1-oxooctyl)amino]-4-octadecen-1-yl]oxy]-1,4-dioxobutyl]-methoxy-poly(oxy-1,2-ethanediyl)
CAS Number
212116-76-2
Synonyms
  • Capryl Ceramide Methoxy Polyethylene Glycol-2000
  • N-Capryl-D-erythro-Sphingosine mPEG(2000)
  • N-Octanoyl-D-erythro-Sphingosine mPEG(2000)
Molecular Formula
(C2H4O)nC31H57NO6
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Sparingly Soluble: 1-10 mg/ml
SMILES
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCC)=O)COC(CCC(OCCOC)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    C8 MPEG(2000) ceramide is a PEGylated form of C8 ceramide (Item No. 62540) that has been used in the generation of lipoplexes and lipid particles for the delivery of plasmid DNA and siRNA in vitro and in vivo.1,2,3 Lipid particles encapsulating plasmid DNA and containing C8 MPEG(2000) ceramide have a higher transfection efficiency than those containing C14- or C20 MPEG(2000) ceramide in BHK cells.1 Lipoplexes containing C8 MPEG(2000) ceramide and encapsulating siRNAs targeting human papillomavirus (HPV) E7 peptide and myeloid cell leukemia-1 (Mcl-1) induce apoptosis in Ca Ski and SiHa cervical cancer cells, which are infected with HPV16.3 Intravaginal administration of lipoplexes containing C8 MPEG(2000) ceramide accumulate in vaginal tissue in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mok, K.W., Lam, A.M., and Cullis, P.R. Stabilized plasmid-lipid particles: Factors influencing plasmid entrapment and transfection properties. Biochim. Biophys. Acta 1419(2), 137-150 (1999).

    2. Saravolac, E.G., Ludkovski, O., Skirrow, R., et al. Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentration for optimal transfection activity. J. Drug Target. 7(6), 423-437 (2000).

    3. Lechanteur, A., Furst, T., Evrard, B., et al. Promoting vaginal distribution of E7 and MCL-1 siRNA-silencing nanoparticles for cervical cancer treatment. Mol. Pharm. 14(5), 1706-1717 (2017).