An MTTP inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SLX-4090

Item No. 41979

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-6-[[[6-methoxy-4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-2(1H)-isoquinolinecarboxylic acid, phenyl ester
CAS Number
913541-47-6
Molecular Formula
C31H25F3N2O4
Formula Weight
546.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mLEthanol: Slightly soluble: 0.1-1 mg/mL
SMILES
COC1=CC=CC(C(NC2=CC=C3C(CCN(C(OC4=CC=CC=C4)=O)C3)=C2)=O)=C1C5=CC=C(C(F)(F)F)C=C5
InChi Code
InChI=1S/C31H25F3N2O4/c1-39-27-9-5-8-26(28(27)20-10-13-23(14-11-20)31(32,33)34)29(37)35-24-15-12-22-19-36(17-16-21(22)18-24)30(38)40-25-6-3-2-4-7-25/h2-15,18H,16-17,19H2,1H3,(H,35,37)
InChi Key
AZUIUVJESCFSLJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $43

    Add

    5 mg

    $161

    Add

    10 mg

    $258

    Add

    25 mg

    $483

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    SLX-4090 is an inhibitor of microsomal triglyceride transfer protein (MTTP; IC50 = 8 nM).1 It selectively inhibits MTTP-mediated secretion of apolipoprotein B (ApoB) over ApoA1 in primary human hepatocytes (IC50s = 81 and >30,000 nM, respectively). In vivo, SLX-4090 reduces postprandial increases in serum triglyceride levels in rats (ED50 = 7 mg/kg). It reduces serum triglyceride levels, weight gain, and total cholesterol levels in ApoE-/- mice fed a high-fat diet when administered at a dose of 5.8 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, E., Campbell, S., Schueller, O., et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: Biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J. Pharmacol. Exp. Ther. 337(3), 775-785 (2011).