1,2,3-Trioleoyl Glycerol-d₅

1,2,3-Trioleoyl glycerol-d₅ is intended for use as an internal standard for the quantification of 1,2,3-trioleoyl glycerol (Item No. 26871) by GC- or LC-MS. 1,2,3-Trioleoyl glycerol is a triacylglycerol that contains oleic acid (Item Nos. 90260 | 24659) at the sn-1, sn-2, and sn-3 positions. It inhibits oxidized LDL-induced decreases in cell viability and superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities and increases in apoptosis in endothelial cells when used at a concentration of 10 μM.¹ 1,2,3-Trioleoyl glycerol has been found in sunflower, corn, and extra virgin olive oils.^2,3 It has been used as a standard for the quantification of triacylglycerols in extra virgin olive oil by high-temperature gas chromatography-(ionic trap)mass spectrometry (HTGC-(IT)MS).³ 1,2,3-Trioleoyl glycerol is a major component of Lorenzo's oil.⁴

WARNING This product is not for human or veterinary use.

1. Luo, T., Deng, Z.Y., Li, X.P., et al. Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells. Lipids 49(5), 495-504 (2014).

2. Gao, B., Luo, Y., Lu, W., et al. Triacylglycerol compositions of sunflower, corn and soybean oils examined with supercritical CO2 ultra-performance convergence chromatography combined with quadrupole time-of-flight mass spectrometry. Food Chem. 218, 569-574 (2017).

3. Ruiz-Samblás, C., Rodríguez-Cuadros, L., González-Casado, A., et al. A straightforward quantification of triacylglycerols (and fatty acids) in monovarietal extra virgin olive oils by high-temperature GC. Anal. Methods 4(3), 753-758 (2012).

4. Moser, H.W., Moser, A.B., Hollandsworth, K., et al. "Lorenzo’s oil" therapy for X-linked adrenoleukodystrophy: Rationale and current assessment of efficacy. J. Mol. Neurosci. 33(1), 105-113 (2007).