A DGAT1 inhibitor
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LCQ-908

Item No. 42025

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]-cyclohexaneacetic acid
CAS Number
956136-95-1
Synonyms
  • Pradigastat
Molecular Formula
C25H24F3N3O2
Formula Weight
455.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
OC(C[C@@H](CC1)CC[C@H]1C(C=C2)=CC=C2C3=CC=C(C=N3)NC4=CN=C(C=C4)C(F)(F)F)=O
InChi Code
InChI=1S/C25H24F3N3O2/c26-25(27,28)23-12-10-21(15-30-23)31-20-9-11-22(29-14-20)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-24(32)33/h5-12,14-17,31H,1-4,13H2,(H,32,33)/t16-,17-
InChi Key
GXALXAKNHIROPE-QAQDUYKDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $30

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    5 mg

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    10 mg

    $179

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    25 mg

    $372

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    LCQ-908 is an inhibitor of diacylglycerol acyltransferase 1 (DGAT1; IC50 = 57 nM).1 It is selective for DGAT1 over DGAT2, acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), and ACAT-2 (IC50s = >10,000 nM for all). LCQ-908 (50 µM) also inhibits hepatitis C virus (HCV) replication in HCV-infected Huh7.5 cells.2 It inhibits palmitic acid-induced apoptosis and increases in triglyceride levels in MIN6 pancreatic β-cells when used at a concentration of 1 µM.3 In vivo, LCQ-908 (1 mg/kg) decreases serum triglyceride levels in an oral lipid tolerance test in dogs.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hong, D.J., Jung, S.H., Kim, J., et al. Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors. J. Enzyme Inhib. Med. Chem. 35(1), 227-234 (2020).

    2. Gane, E., Stedman, C., Dole, K., et al. A diacylglycerol transferase 1 inhibitor is a potent hepatitis C antiviral in vitro but not in patients in a randomized clinical trial. ACS Infect. Dis. 3(2), 144-151 (2017).

    3. Huang, J.-S., Guo, B.-B., Wang, G.-H., et al. DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis. Acta Pharmacol. Sin. 42(2), 264-271 (2021).