A PDHK inhibitor
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PS-10

Item No. 42068

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,4-dihydroxyphenyl)sulfonyl]-2,3-dihydro-1H-isoindole-4,6-diol
CAS Number
1564265-82-2
Molecular Formula
C14H13NO6S
Formula Weight
323.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 0.1-1 mg/ml
SMILES
O=S(N1CC2=C(C1)C(O)=CC(O)=C2)(C3=CC=C(O)C=C3O)=O
InChi Code
InChI=1S/C14H13NO6S/c16-9-1-2-14(13(19)4-9)22(20,21)15-6-8-3-10(17)5-12(18)11(8)7-15/h1-5,16-19H,6-7H2
InChi Key
SVUZJWAAXPEMKJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $104

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    10 mg

    $192

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    PS-10 is an inhibitor of pyruvate dehydrogenase kinase (PDHK; IC50s = 2.07, 0.8, 21.3, and 0.77 µM for PDHK1, -2, -3, and -4, respectively).1 It selectively binds to PDHK2 over heat shock protein 90 (Hsp90; Kds = 0.239 and 47 µM, respectively). PS-10 (70 mg/kg) increases heart, liver, and kidney pyruvate dehydrogenase complex activity, decreases blood glucose levels in a glucose tolerance test, and reduces plasma lactate, cholesterol, and triglyceride levels, fat mass, and hepatic lipid accumulation in a mouse model of high-fat diet-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tso, S.-C., Qi, X., Gui, W.-J., et al. Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket. The Journal of Biological Chemisty 289(7), 4432-4443 (2014).