A prodrug form of 7,8-dihydroxyflavone
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Active Metabolite(s)
169467,8-Dihydroxyflavone
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TrkB Agonist Prodrug R13

Item No. 42074

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8-bis[[(methylamino)carbonyl]oxy]-2-phenyl-4H-1-benzopyran-4-one
CAS Number
1609067-49-3
Synonyms
  • TrkB-IN-1
  • Tropomyosin-related Kinase B Agonist Prodrug R13
  • Tropomyosin-related Kinase B Inhibitor 1
Molecular Formula
C19H16N2O6
Formula Weight
368.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NC)OC1=C(OC(C2=CC=CC=C2)=CC3=O)C3=CC=C1OC(NC)=O
InChi Code
InChI=1S/C19H16N2O6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10H,1-2H3,(H,20,23)(H,21,24)
InChi Key
NWWRHMSYZTWUBD-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

    $491

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    Cayman Chemical
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    Product Description

    TrkB agonist prodrug R13 (R13) is a prodrug form of the tropomyosin-related kinase B (TrkB) activator 7,8-dihydroxyflavone (Item No. 16946).1 Oral administration of R13 (43.6 mg/kg per day) increases hippocampal phosphorylated levels of TrkB, ERK, and Akt in the 5XFAD transgenic mouse model of Alzheimer's disease. It decreases the number of malformed neurons and increases the number of neurons and active synapses in the hippocampus in 5XFAD mice. R13 decreases the number of plaques and levels of amyloid-β (1-40) (Aβ40) in the hippocampus and frontal cortex and escape latency in the Morris water maze in 5XFAD mice. It reduces the levels and activity of δ-secretase, also known as asparagine endopeptidase (Aep) and legumain, and the levels of Il-6, Tnf-α, and Il-1β in brain homogenates from 5XFAD mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, C., Wang, Z., Zhang, Z., et al. The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease. Proc. Natl. Acad. Sci. U S A 115(3), 578-583 (2018).