An Oct4 inducer and CCR4 antagonist
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O4I4

Item No. 42088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(1,1-dimethylethyl)-N-(2,3-dimethylphenyl)-2-thiazolamine
CAS Number
412008-21-0
Synonyms
  • Oct4-inducing Compound 4
Molecular Formula
C15H20N2S
Formula Weight
260.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=CC=CC(NC2=NC(C(C)(C)C)=CS2)=C1C
InChi Code
InChI=1S/C15H20N2S/c1-10-7-6-8-12(11(10)2)16-14-17-13(9-18-14)15(3,4)5/h6-9H,1-5H3,(H,16,17)
InChi Key
DNOVKAUCGLWSEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $90

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    10 mg

    $152

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    25 mg

    $310

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    Product Description

    O4I4 is an inducer of octamer-binding transcription factor 4 (Oct4).1 It is also an antagonist of chemokine (C-C motif) receptor 4 (CCR4; IC50 = 0.26 µM).2 O4I4 induces transactivation of Oct4 and Nanog in a reporter assays using NCCIT pluripotent stem cells.1 It increases the lifespans of C. elegans and Drosophila when used at concentrations of 0.5 and 20 µM, respectively. O4I4, in combination with O4I3 and SOX2, Kruppel-like factor 4 (KLF4), L-Myc, and Lin28 (SKML), induces formation of three germ layers in teratomas in a mouse model of differentiation using human chemically induced PSCs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, H., Hasselbeck, S., Taškova, K., et al. Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo. Eur. J. Med. Chem. 257, 115513 (2023).

    2. Wang, X., Xu, F., Xu, Q., et al. Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg. Med. Chem. Lett. 16(10), 2800-2803 (2006).