An RNF5 inhibitor and degrader
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FX12

Item No. 42089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1-dioxide, benzo[b]thiophene-2-carboxylic acid, methyl ester
CAS Number
1807639-36-6
Molecular Formula
C10H8O4S
Formula Weight
224.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC2=C(S1(=O)=O)C=CC=C2)OC
InChi Code
InChI=1S/C10H8O4S/c1-14-10(11)9-6-7-4-2-3-5-8(7)15(9,12)13/h2-6H,1H3
InChi Key
QQJKRTQSVNKTLM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $203

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    10 mg

    $378

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    Product Description

    FX12 is an inhibitor and degrader of the E3 ubiquitin ligase RNF5.1 It binds to RNF5 and inhibits its E3 ligase activity in cell-free assays. FX12 (1.25-20 µM) induces proteasomal degradation of RNF5 via the endoplasmic reticulum-associated proteasomal degradation (ERAD) pathway without modifying mRNA levels in HeLa cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruan, J., Liang, D., Yan, W., et al. A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase. Mol. Biol. Cell 33(13), ar120 (2022).