A DP receptor antagonist
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Prostaglandin D2 Inhibitor

Item No. 42095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-benzeneacetic acid
CAS Number
885066-67-1
Synonyms
  • PGD2-IN-1
  • PGD2 Inhibitor
  • PGD2 Inhibitor 1
  • Prostaglandin D2-IN-1
  • Prostaglandin D2 Inhibitor 1
Molecular Formula
C23H23Cl2N3O3
Formula Weight
460.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C(C)(C)C1=CC=CC(C2=CC(NCCC3=CC=C(Cl)C=C3Cl)=NC(OC)=N2)=C1)O
InChi Code
InChI=1S/C23H23Cl2N3O3/c1-23(2,21(29)30)16-6-4-5-15(11-16)19-13-20(28-22(27-19)31-3)26-10-9-14-7-8-17(24)12-18(14)25/h4-8,11-13H,9-10H2,1-3H3,(H,29,30)(H,26,27,28)
InChi Key
FJKKCRCBBAXLQZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Prostaglandin D2 (PGD2) inhibitor is an antagonist of PGD2 receptor (DP; IC50 = 0.3 nM).1 It inhibits PGD2-induced cAMP accumulation in LS 174T cells that endogenously express the DP receptor.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mu, L., Aguiar, J., Ardati, A., et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg. Med. Chem. Lett. 21(1), 66-75 (2011).