An antagonist of NR1A/2B subunit-containing NMDA receptors
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TCS 46b

Item No. 42123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-2H-benzimidazol-2-one
CAS Number
302799-86-6
Molecular Formula
C22H23N3O
Formula Weight
345.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1NC2=CC(C#CCN3CCC(CC3)CC4=CC=CC=C4)=CC=C2N1
InChi Code
InChI=1S/C22H23N3O/c26-22-23-20-9-8-18(16-21(20)24-22)7-4-12-25-13-10-19(11-14-25)15-17-5-2-1-3-6-17/h1-3,5-6,8-9,16,19H,10-15H2,(H2,23,24,26)
InChi Key
JJEXWPHPFZLTCU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $80

    Add

    10 mg

    $151

    Add

    25 mg

    $357

    Add

    50 mg

    $634

    Add
    Product Description

    TCS 46b is an antagonist of NMDA receptors containing NR1A/2B subunits (IC50 = 0.0053 µM).1 It is selective for NMDA receptors containing NR1A/2B subunits over NMDA receptors containing NR1A/2A and NR1A/2C subunits (IC50s = 35 and >100 µM, respectively). TCS 46b (10 mg/kg) inhibits L-DOPA-induced contralateral rotations in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330). It has been radiolabeled and used as an NR1A/2B-selective PET radiotracer.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wright, J.L., Gregory, T.F., Kesten, S.R., et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J. Med. Chem. 43(18), 3408-3419 (2000).

    2. Roger, G., Lagnel, B., Besret, L., et al. Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer. Bioorg. Med. Chem. 11(24), 5401-5408 (2003).