A potentiator of insulin-induced Glut4 plasma membrane translocation
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Insulin Sensitizer C59

Item No. 42129

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4,5-dichloro-2-pyridinyl)-tricyclo[3.3.1.13,7]decane-1-carboxamide
CAS Number
2761446-81-3
Synonyms
  • C59
Molecular Formula
C16H18Cl2N2O
Formula Weight
325.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC(N=C4)=CC(Cl)=C4Cl
InChi Code
InChI=1S/C16H18Cl2N2O/c17-12-4-14(19-8-13(12)18)20-15(21)16-5-9-1-10(6-16)3-11(2-9)7-16/h4,8-11H,1-3,5-7H2,(H,19,20,21)/t9-,10+,11-,16?
InChi Key
RBBBMHRIAFVEFR-NROJINRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $104

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    25 mg

    $213

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    Cayman Chemical
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    Product Description

    Insulin sensitizer C59 is a potentiator of insulin-induced plasma membrane translocation of glucose transporter 4 (Glut4).1 It enhances insulin-stimulated increases in plasma membrane levels of Glut4 in a reporter assay using C2C12 cells when used at a concentration of 10 µM. Insulin sensitizer C59 (10 mg/kg per day) decreases fasting blood levels of glucose, fasting plasma levels of insulin, and body weight in mice fed a high-fat diet. It potentiates insulin-induced increases in the plasma membrane translocation of Glut4 in the forelimbs, hind limbs, brown adipose tissues, and heart but not brain or liver in mice in a model of diet-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yin, T.C., Van Vranken, J.G., Srivastava, D., et al. Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell Chem. Biol. 30(8), 933-942 (2023).