A potentiator of insulin-induced Glut4 plasma membrane translocation
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Insulin Sensitizer C59

Item No. 42129

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4,5-dichloro-2-pyridinyl)-tricyclo[3.3.1.13,7]decane-1-carboxamide
CAS Number
2761446-81-3
Synonyms
  • C59
Molecular Formula
C16H18Cl2N2O
Formula Weight
325.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC(N=C4)=CC(Cl)=C4Cl
InChi Code
InChI=1S/C16H18Cl2N2O/c17-12-4-14(19-8-13(12)18)20-15(21)16-5-9-1-10(6-16)3-11(2-9)7-16/h4,8-11H,1-3,5-7H2,(H,19,20,21)/t9-,10+,11-,16?
InChi Key
RBBBMHRIAFVEFR-NROJINRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $104

    Add

    25 mg

    $213

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Insulin sensitizer C59 is a potentiator of insulin-induced plasma membrane translocation of glucose transporter 4 (Glut4).1 It enhances insulin-stimulated increases in plasma membrane levels of Glut4 in a reporter assay using C2C12 cells when used at a concentration of 10 µM. Insulin sensitizer C59 (10 mg/kg per day) decreases fasting blood levels of glucose, fasting plasma levels of insulin, and body weight in mice fed a high-fat diet. It potentiates insulin-induced increases in the plasma membrane translocation of Glut4 in the forelimbs, hind limbs, brown adipose tissues, and heart but not brain or liver in mice in a model of diet-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yin, T.C., Van Vranken, J.G., Srivastava, D., et al. Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell Chem. Biol. 30(8), 933-942 (2023).